Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets 5'-oligoadenylates (2-5As)

5'-oligoadenylates (2-5As)

Multiple capacities and well configurations are available for different experimental needs

A pseudogene corresponding to this gene is found on chromosome 20

Originally localized to both chromosomes 2 and 7

and is capable of inducing experimental autoimmune uveoretinitis

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets 5'-oligoadenylates (2-5As)The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.