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Back Eng, J (1993) 'Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same', US Patent 5,424,286

In animal studies, Semaglutide demonstrated neuroprotective and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein regulating the innate immune system and inflammatory responses

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PMC 4020673