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In turn, those SCFAs signal cells in the gut to release GLP-1 into the bloodstream

The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

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Excess weight increases the risk of type 2 diabetes, high blood pressure, heart disease, fatty liver disease, sleep apnea, joint pain, stroke, and some cancers

Materials and methods Cell lines MCF-7, ZR-75-1, and T47D human breast cancer cell lines and HEK293T17 cells were purchased from the American Type Culture Collection (ATCC, Maryland, USA)