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Emotional and psychological factors can also contribute to obesity

21 While not assessed directly in our study, crude comparison of the incidences of GI AEs reported in the individual STEP 1, 2 and 3 trials 8 , 9 , 10 indicates betweentrial variation in incidences for both semaglutide 2.4 mg and placebo arms, which may reflect trialspecific differences in design and patient populations

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From a process development standpoint, peptide manufacturing is sensitive to synthesis conditions, purification efficiency, and storage