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Consuming high amounts of protein from protein-rich food sources is unlikely to cause any negative side effects

But it failed to demonstrate significant weight loss in six clinical trials, and its development was terminated because of those failures

6.1 Cross-pathogen mechanistic convergence and divergence in mitochondrial dysfunction Although distinct in biology, viruses, bacteria, fungi, and parasites exploit overlapping mitochondrial vulnerabilities

Much of this evidence comes from preclinical models, so human conclusions remain limited

After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency