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doi: 10.1128/MCB.22.11.3565-3576.2002

Retatrutide (LY3437943) is a single peptide engineered to agonise three incretin-family receptors at once: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR) 26

Stacking peptides like CJC-1295 with Ipamorelin is a common clinical strategy to mimic the natural pulsatile release of growth hormone seen in younger adults

The group at risk of endometrial hyperplasia are those women using a GLP-1 and also using TD oestrogen (which will be unaffected by the GLP-1 agonist) and an oral progestogen, as the absorption of the progestogen may be reduced while the oestrogen stays the same, leaving the woman with an unbalanced regime and an insufficient amount of progestogen to protect her endometrium from the oestrogen