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Thus, BZ/NFX, at appropriate concentration, would decrease the availability of low MW thiols such that oxygen redox cycling-derived free radicals, drug-derived free radicals, and reduced electrophilic metabolites are accumulated and cause cytotoxic effects on the parasite biomolecules (Maya et al., 1997)

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The compounds discussed are investigational and, unless otherwise noted, have not been approved for human therapeutic use by Health Canada or any other regulatory body

One connection is that low vitamin B6 interacts with IL-33 , an inflammatory cytokine often involved in asthma or COPD

They are now recommended for many people with: Heart failure Ongoing coronary artery disease Kidney disease DiabetesFirst developed to lower blood sugar and treat diabetes, SGLT2 inhibitors are important heart medicines too