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Follistatin-344 produces equivalent or greater systemic effect (+1014% CSA contralateral) due to circulating myostatin neutralisation acting on all skeletal muscle beds simultaneously

Abstract Purposeof Review To outline the current landscape of treatments for Leber hereditary optic neuropathy (LHON) along the therapeutic delivery pipeline, exploring the mechanisms of action and evidence for these therapeutic approaches

The translation of the IGF-1 gene gives rise to an immature IGF-1 peptide, which has a signal peptide at the 5 end of the gene, a core region and a C-terminal E-domain extension