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p = 0.017), and IL-23 ( = 0.723

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

Its primary role is to upregulate proteins like actin, which is critical for cell migration, proliferation, and differentiation

DSIP is studied for its effects on sleep regulation, circadian rhythms, stress response, and neuroendocrine function