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In summary, clarifying the link between the gut-joint axis and ferroptosis in OA would be of great significance not only for better understanding the pathological processes at multi-levels (local joint tissues, the gut environment, and circulation), but also from a unique angle for guiding novel therapies development in OA Deep investigative approach to understand how major gut bacterial metabolites (tryptophan-derived metabolites, TMAO and so on) modulate ferroptosis in OA is very promising to elucidate the central regulatory mechanism acted by the gut-joint axis on ferroptosis in OA

To view or add a comment, sign in GLP-1 medications, including Ozempic, Wegovy, Mounjaro, and Zepbound, are currently involved in significant pharmaceutical litigation in the United States

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Discussion The present study offers novel insights into the therapeutic potential of GLP-1 agonists in the context of RV dysfunction

A patient on Wegovy 2.4 mg who switches to Zepbound 5 mg is not guaranteed the same response