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risk difference, 0%, P = .827)

Dysesthesia: A New Signal for Retatrutide The TRIUMPH-4 Phase 3 trial revealed an unexpected finding: dysesthesia (abnormal touch sensations where normal sensations feel unusual or painful) in 20.9% of participants on 12 mg and 8.8% on 9 mg, compared to 0.7% on placebo (BioSpace, Dec 2025)

Tirzepatide body aches tend to be transient and manageable with adequate hydration, electrolyte supplementation, and gentle movement

However, Roche surely hopes that Carmots weight loss pipeline will be worth the wait Carmots leading candidate is known as CT-388, a Phase 2-ready weekly GLP-1/GIP injection that, like Lillys tirzepatide, activates both GIP (affects adipose tissue regulation and storage) and GLP-1 (increases feeling of fullness and decreases gastric emptying) hormone receptors