GSK126 - EZH2 Methyltransferase Inhibitor. CAS# 1346574-57-9 size:2mg solid and has moderate inhibitory activity

and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1

(2013) Bioorg Med Chem Lett

InChi: InChI=1S/C18H15NO4/c1-19(11-12-5-3-2-4-6-12)14-8-7-13-9-15(17(20)21)18(22)23-16(13)10-14/h2-10H

Johnson AJ

CAS Number: 603288-22-8

GSK126 - EZH2 Methyltransferase Inhibitor. CAS# 1346574-57-9 size:2mg solid and has moderate inhibitory activityGSK126, CAS No. 1346574 57 9, is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2. It potently inhibits both wild type and mutant EZH2 methyltransferase activity with similar potencies (Kiapp 0. 53 nM), independent of substrate used, and is competitive with S adenosylmethionine (SAM) and non competitive with peptide substrates. GSK126 is highly selective against other methyltransferases and multiple other