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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas

GLP-1R is expressed by various populations of central neurons, but it is still not fully clear which specific populations mediate the effects of GLP-1RAs

It reduces inflammation A diet high in protein, particularly plant-based protein, may help reduce inflammation in the body in older populations (9)

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Side effects you should expect (and when to worry) Side effects with GLP-1 medications are not a sign that something is wrong