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The evidence base behind semaglutide Semaglutide's weight-management data come chiefly from the STEP trial program, published in The New England Journal of Medicine in 2021

PMID: 7 FerrazEBorgesMCTerra-FilhoJMartinezJAViannaEO

Proposed explanations include GIP-mediated insulin sensitisation, adipocyte-biology changes favouring healthier fat distribution, and central effects that enhance appetite signalling from GLP-1R activation